Accès direct au contenu

avancée

Département de Biologie

Accès rapides

Actualités

Accueil > Actualités

    Biologie

    Séminaire Départemental - Mme. Jacqueline CHERFILS

    le 5 décembre 2013
    à 11h - Amphi Curie
    Ecole Polytechnique,

    Traffic logistics in cells: how they are organized by small GTPases and their regulators

    Mme. Jacqueline CHERFILS
    Directrice  du Laboratoire d'Enzymologie et Biochimie Structurales,
    CNRS, Gif-sur-Yvette, France

    Membrane traffic is the “cellular postal service” that shuttles biomolecules around the cell and organizes the structure of organelles. Long-standing interest in my group has been to elucidate the biochemistry, structure and dynamics of small GTPases machineries that underly their coordination of cellular traffic logistics. To that end, we develop multidisciplinary approaches that include notably structural biochemistry, chemical biology of small molecule inhibitors, and cell biology. I will present some of our recent results on trafficking Arf and Rab GTPases, which are chief organizers of membrane traffic and cytoskeleton dynamics. I will notably focus on the activation of Arf GTPases by their guanine nucleotide exchange factors (ArfGEFs) in the normal cell and in diseases. Our studies uncovered that human and bacterial ArfGEFs have an unexpected diversity of regulatory mechanisms, which suggests that some ArfGEFs, if not all, combine in feedback circuits to shape the level, localization and timing of Arf activation on cellular membranes. These findings open exciting perspectives at the interface of innovative methods in structural biochemistry, mathematical biology, chemical biology, and high resolution imaging of live cells.
    Lieu(x) :
    à 11h - Amphi Curie, Ecole Polytechnique
    Contact :
    Yves Mechulam
    À télécharger :